Shake product well before using. Mix appropriate volume of ShrimpFlorinBacterClean (see below) with 250-ml (~8 fl. oz.) of aquarium water in a clean container prior to addition to aquarium. If using a pipette to dispense ShrimpFlorinBacterClean below water level of container or aquarium, be sure to thoroughly clean pipette with fresh (preferably purified) water prior to placing tube back into ShrimpFlorinBacterClean bottle; failure to do so will contaminate the product. Best results may be obtained by adding mixture to external biological filtration system (if applicable). Do not add to pump intake port(s), which can negatively impact the microbes present in ShrimpFlorinBacterClean. For best results, use within 1-year of purchase date.